Throat cancer patient with arms folded

Throat cancer

The information on this page was reviewed and approved by
Maurie Markman, MD, President, Medicine & Science at CTCA.

This page was updated on September 1, 2021.

Diagnosing throat cancer

A thorough and accurate cancer diagnosis is the first step in developing a throat cancer treatment plan. At Cancer Treatment Centers of America® (CTCA), our experts use a wide range of tools and technologies designed for diagnosing throat cancer and evaluating the disease, with an emphasis on speed to care and timely results. Within the first two days of the patient’s arrival at our hospital, we will perform a complete array of diagnostic tests and thoroughly review the person’s medical records and health history. Doctors will also likely conduct a physical exam. This information helps us formulate treatment recommendations tailored specifically for each patient.

Throat cancers may develop in different parts of the throat. Some throat cancers start in the voice box (the larynx), also called laryngeal cancers. Others start in the lower part of the throat (the hypopharynx), also called hypopharyngeal cancers. The most common type of cancer in the larynx and hypopharynx is squamous cell carcinoma, because it develops within the squamous cells lining these areas.

Rarer types of throat cancer include:

Throat cancers are typically discovered due to the symptoms they cause, so it’s important to watch for early signs and symptoms. These may differ depending on where the cancer starts within the throat.

The tests you may undergo include those listed below.


A sample of throat tissues or cells is required for a biopsy, which must be conducted before treatment begins. The types of biopsies typically used for diagnosing throat and other head and neck cancers are:

Endoscopic biopsy: An instrument called an endoscope is inserted into one of the nostrils or the mouth. The endoscope has a light and a video camera on one end, which allows the surgeon to see the area being biopsied. The endoscope is also hollow, which allows the surgeon to pass instruments through it. These instruments are used to remove a sample from an abnormal-looking area.

Incisional biopsy: In this procedure, a small piece of tissue is cut from an abnormal-looking area. Because the larynx is deep inside the neck, removing samples involves a complex procedure. Biopsies in this region are usually performed in an operating room, with general anesthesia administered to prevent pain.

Fine needle aspiration (FNA)A very thin needle attached to a syringe is used to extract (aspirate) cells from a tumor or lump.

Imaging tests

Various imaging tests may be performed to help formulate a throat cancer diagnosis, including:

CT scan: A CT scan may provide information about the size, shape and position of any tumors, and may also help identify enlarged lymph nodes that may contain cancer cells.

Barium swallow: A barium swallow test may show irregularities in the different parts of the throat, and may often detect small, early tumors.

Magnetic resonance imaging (MRI): Commonly, an MRI scan may be used to examine throat cancer. MRIs provide a very detailed view, and may help determine whether or not the cancer has spread, either to other areas in the neck or other regions of the body.

Positron emission tomography (PET): For patients diagnosed with throat cancer, a PET/CT scan may be used to see if cancer has spread to the lymph nodes, to determine the origin of cancer when it is found in the lymph nodes first, or to check the body for the spread of cancer cells.

X-ray: An X-ray of the chest may be taken to check if the cancer has spread to the lungs. Cancer will not be present in the lungs unless it has advanced.

Other diagnostic procedures

Other diagnostic procedures for throat cancer evaluations often involve some type of scope used to inspect the deeper areas of the throat. For example:

Panendoscopy: This is a diagnostic test used to examine the upper digestive system, including the larynx, esophagus, stomach and first part of the small intestine. In this exam, an individual is given general anesthesia in an operating room so that the entire region of the body can be closely inspected for cancer. Endoscopes are used to look at the back of the throat, larynx, esophagus and possibly the windpipe (trachea) and bronchi. Other parts of your nose, mouth and throat, including the trachea (windpipe) and esophagus, are also examined during this procedure. The doctor performing the procedure will look for any visible signs of a tumor. Doctors may use a special instrument through the scope to biopsy pieces of tissue that look potentially cancerous.

Laryngoscopy: For this procedure, your doctor may spray your nose or the back of your throat with a numbing medicine to avoid pain. Because throat cancers are close to other areas of the head and neck, your doctor may also examine your mouth, nose and neck.

Pharyngoscopy: Like with a laryngoscopy, the doctor may use a spray to numb the back of your throat. Because pharyngeal cancer raises risk for other head and neck cancers, your doctor will also examine the mouth, tongue, larynx and neck for signs of abnormalities.

Understanding test results

The results from imaging tests and a biopsy help confirm a cancer diagnosis, including where it may be located and whether it has spread.

Many of the tests performed to help diagnose throat cancer also help determine the stage. Throat cancer stages range from 1 to 4. The stage of the cancer indicates how far it has spread from its original location, which will impact how the cancer will be treated and how serious it is.

Next topic: How is throat cancer treated?

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